Serology & Infectious Disease Billing Services To Recover Every Dollar You've Earned

Most serology and infectious disease labs lose 15-20% of collectible revenue annually; not from low test volume, but expanded panel medical necessity denials, NAAT target-count miscoding, and reflex confirmatory testing gaps that generalist billers miss entirely. TransLabs’ certified infectious disease billing specialists close those gaps with a 98% clean claims rate and 30% faster A/R, with measurable growth in 90 days.
Serology and Infectious Disease Billing Services
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Why Serology and Infectious Disease Laboratories Lose Revenue Every Single Day

Serology and infectious disease billing moves faster than almost any lab discipline; new multiplex panels, PLA codes, and payer scrutiny arrive yearly, often reacting to the last outbreak or audit. Expanded syndromic panels that once sailed through now face target-count limits and non-coverage determinations. Generalist billers rarely track these changes, and revenue loss compounds quietly until an audit reveals months of costs.

The Five Revenue Leaks Most Serology & Infectious Disease Labs Don't Know They Have

Expanded Panel Medical Necessity Denials

NAAT Target-Count Miscoding

Reflex Confirmatory Testing Capture Gaps

Add-On Test Bundling With Primary Infectious Disease Testing

Screening vs. Diagnostic Coding Errors

Serology and Infectious Disease Billing Services

Every Serology and Infectious Disease Testing Category, Billed Correctly; From Specimen to Final Payment

From single-analyte serology to expanded multiplex molecular panels, our AAPC and AHIMA certified coders know the CPT coding rules, the target-count logic, and the payer-specific medical necessity requirements for every category of serology and infectious disease testing.

Respiratory Pathogen Panels

CPT 87631--87633, 87636--87637

Multiplex nucleic acid detection of respiratory viruses and select bacteria at 3-5 targets (87631), 6-11 targets (87632), and 12-25 targets (87633), plus combined SARS-CoV-2/influenza panels (87636, 87637).

Key Billing Consideration

Medicare and most commercial payers now limit expanded panels (87632, 87633) to beneficiaries with serious illness, immunodeficiency, or a documented severe underlying condition --- billing an expanded panel as routine outpatient triage testing is one of the fastest-growing denial and audit triggers in this category.

Gastrointestinal Pathogen Panels

CPT 87505--87507

Multiplex nucleic acid detection of GI bacterial, viral, and parasitic pathogens at 3-5 targets (87505), 6-11 targets (87506), and 12-25 targets (87507), used to work up infectious diarrhea and suspected enteric pathogens.

Key Billing Consideration

The same payer scrutiny applied to expanded respiratory panels extends to GI panels --- 87507 in particular draws frequent post-payment review, and claims without a documented reason the broader panel was clinically necessary are routinely denied.

Sexually Transmitted Infection (STI) NAAT Testing

CPT 87491, 87591, 87801

Nucleic acid amplification testing for chlamydia (87491) and gonorrhea (87591), often ordered as a combined panel, plus multiplex STI panels detecting multiple organisms from a single specimen (87801).

Key Billing Consideration

Screening-context STI testing must be coded and billed differently from diagnostic testing performed for symptomatic patients --- using the wrong benefit category is a routine source of unexpected patient cost-sharing disputes and claim rejections.

Hepatitis Serology & Molecular Panels

CPT 80074, 86803--86804, 87516--87522

Acute hepatitis panels (80074), hepatitis C antibody screening (86803) and confirmatory testing (86804), and quantitative or qualitative hepatitis B and C nucleic acid testing (87516-87522) used for diagnosis, treatment monitoring, and cure confirmation.

Key Billing Consideration

One-time hepatitis C screening and risk-based repeat screening follow different coverage rules --- billing a repeat screen without documenting the specific risk factor that justifies it is a common and avoidable denial.

HIV Screening & Confirmatory Testing

CPT 86689, 86701--86703, 87389--87390

HIV-1 antibody confirmation (86689), combined HIV-1/HIV-2 antibody screening (86701-86703), and antigen/antibody combination immunoassay screening (87389, 87390) used across preventive screening and diagnostic workups.

Key Billing Consideration

A reactive screening result must reflex to the correct confirmatory test and be billed as a distinct, medically necessary service --- failing to capture the confirmatory step, or billing it as a duplicate screen, is a frequent source of both underbilling and denial.

Syphilis & Lyme Disease Two-Tier Testing

CPT 86592--86593, 86617--86619

Non-treponemal syphilis screening (86592) and treponemal confirmatory testing (86593), plus Lyme disease two-tier testing combining an initial screening immunoassay (86618) with confirmatory immunoblot (86617, 86619).

Key Billing Consideration

Two-tier testing protocols require the confirmatory test to reflex specifically from a positive or equivocal screen --- billing the confirmatory tier without a documented reactive first-tier result is a compliance exposure, not just a coding gap.

Tuberculosis Interferon-Gamma Release Assay (IGRA) Testing

CPT 86480--86481

Interferon-gamma release assay testing for tuberculosis infection using a single antigen mixture (86480) or peptide-based antigen response measured by cell count (86481), used as an alternative to tuberculin skin testing.

Key Billing Consideration

IGRA testing frequency limits and the specific ICD-10 linkage required to support medical necessity vary by MAC --- claims billed outside the documented occupational or clinical screening indication are routinely flagged.

Sepsis & Acute Infection Biomarkers

CPT 84145, 86140--86141

Procalcitonin testing (84145) used to support sepsis risk stratification and antibiotic stewardship decisions, and C-reactive protein testing, standard (86140) or high-sensitivity (86141), used to monitor acute inflammatory and infectious processes.

Key Billing Consideration

Procalcitonin and CRP testing ordered on a fixed daily schedule rather than tied to a documented change in clinical status is a routine medical necessity denial driver, particularly in higher-frequency inpatient and post-acute settings.

Our Laboratory RCM Services

TransLabs’ specialized RCM services are built exclusively for labs, addressing the unique challenges that generalist billers miss. We provide end-to-end revenue cycle solutions designed specifically to turn laboratory complexity into profitability.

Proficient Across Multiple LIS & EHRs to Simplify Your
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Serving Labs Across The United States

TransLabs provides expert RCM services to clinical laboratories in all 50 states, delivering the same exceptional results whether you’re a community hospital lab or a large reference facility. We bring specialized lab billing expertise to facilities nationwide, combining remote efficiency with hands-on partnership.

Medicare Part B Compliance for Serology and Infectious Disease Laboratories

Infectious disease billing compliance has tightened considerably since the expansion of multiplex molecular testing. Payers and federal program integrity efforts now scrutinize expanded panel utilization specifically, and the coverage rules change often enough that a policy your lab relied on last year may already be outdated. TransLabs tracks these changes continuously and builds the resulting documentation requirements directly into your billing workflow.
Expanded Panel Coverage Determinations

Many MACs and commercial payers now treat 6-11 and 12-25 target respiratory and GI pathogen panels as non-covered or covered only for beneficiaries with serious illness, immunodeficiency, or a documented severe underlying condition. TransLabs validates every expanded panel claim against the current coverage determination before submission, not after the denial.

Local Coverage Determinations & Coding Articles for Molecular Panels

Each MAC maintains its own LCD and companion coding article specifying which ICD-10 diagnoses support coverage for respiratory, GI, and other multiplex infectious disease panels. These policies are revised frequently as new PLA codes are added and older ones retired. TransLabs maintains live LCD databases and validates diagnosis-to-test linkage on every Medicare claim.

Reflex & Two-Tier Testing Documentation

Two-tier protocols, such as Lyme disease screening followed by confirmatory immunoblot, or a reactive HIV screen followed by confirmatory testing, must show the reflex logic was followed correctly. TransLabs builds these reflex rules directly into claim validation so confirmatory testing is billed only when the record supports it.

Add-On Testing Program Integrity Monitoring

Federal program integrity efforts have specifically flagged the practice of bundling unrelated add-on tests, such as allergy or genetic panels, alongside a primary infectious disease test without independent medical necessity for each service. TransLabs reviews ordering patterns for this exact risk profile.

Advance Beneficiary Notices for Non-Covered Panel Tiers

When an expanded panel tier may not meet medical necessity criteria under the applicable LCD, a valid ABN must be issued before the specimen is collected. TransLabs implements ABN workflows into front-end intake specifically for expanded respiratory and GI panel ordering.

Screening vs. Diagnostic Benefit Category Coding

Preventive screening for HIV, hepatitis C, and select STIs falls under a different benefit category than diagnostic testing for symptomatic patients, with different cost-sharing rules. TransLabs codes each claim to the correct benefit category based on the documented reason for testing.

Clinical Laboratory Fee Schedule (CLFS)

The CLFS sets Medicare payment rates for serology and infectious disease lab tests and updates annually on January 1, with molecular panel codes revised more frequently than most categories. TransLabs monitors CLFS changes and updates billing tables immediately at each rate change.

We Bill Only for Laboratories and That Difference Shows in Every Metric We Track

Most billing companies still bill infectious disease panels the way they did three years ago, missing the coverage changes that have reshaped expanded panel reimbursement since. TransLabs was built for laboratory billing exclusively, and our infectious disease team tracks payer policy changes as they happen, not months after a denial pattern has already cost you money.

Serology & Infectious Disease-Exclusive Specialization

Infectious disease is the focus, not an afterthought; NAAT target-count coding, two-tier reflex logic, and expanded panel medical necessity, done right.

98% First-Pass Clean Claims Rate

98%+ clean claims rate across all lab clients with fewer denials, faster payments, stronger cash flow.

Real-Time Coverage Policy Monitoring

We track LCD and payer policy changes for molecular panels continuously; catching non-coverage before it becomes a wave of denials.

High-Complexity Test Architecture

Purpose-built for infectious disease; target counts, reflex triggers, screening-vs-diagnostic coding, not retrofitted from routine chemistry.

No Long-Term Contracts

Month-to-month, results-based partnership with measurable improvement in 90 days, no exit fees, just 30 days’ notice.

Transparent Reporting

Monthly dashboards with full visibility of clean claims rate, denial trends, A/R aging, and root cause analysis, no surprises.

Get Your Lab's Custom Revenue Recovery Plan

Schedule a call with our serology and infectious disease billing specialist. We’ll review your expanded panel coverage exposure, reflex testing capture, target-count accuracy, and A/R days.

What Our Clients Say?

Linda Hutchinson
Linda Hutchinson
Laboratory Director
Our NGS panel denials dropped from 32% to under 6% within three months. TransLabs' expertise with molecular tier codes, prior authorization management, and LCD compliance has been invaluable. They understand the nuances of genetic testing billing that our previous vendor completely missed.
Peter Wozniak
Peter Wozniak
Pathologist & Laboratory Owner
We've worked with three other billing companies over the years. TransLabs is the only one that truly understands complex surgical pathology coding, immunohistochemistry billing, and the nuances of TC/PC modifiers. Clean claims rate improved to 99%, and our dermatopathology reimbursement increased 27%.
James Patton
James Patton
Cytogenetics Laboratory Manager
Before TransLabs, our FISH and karyotype claims were a constant struggle with denials and underpayments. Their coders actually understand probe configurations, complexity levels, and when to use 88271 versus 88275. Our cytogenetics revenue increased 34% in the first year.

Book Consultation Today!

Stop Leaving Reimbursements on the Table

Join 500+ diagnostic and clinical laboratories that trust TransLabs, the laboratory billing company built for growth. Start with our complimentary claims audit. Our serology and infectious disease billing specialists will review your expanded panel coding, your reflex testing capture, and your denial trends to show you exactly what’s recoverable.

Dedicated billing specialist assigned to your lab

Complimentary 12-month claims audit across Medicare, Medicaid, and commercial payers

Uncover your top 3 revenue leaks (expanded panel denials, reflex gaps, coding mismatches)

Custom strategy tailored to your test menu and LIS/billing software

Live in 24 hours with no contracts and no upfront fees

Pay only a percentage of what we collect for you

Frequently Asked Questions

Why are expanded respiratory and GI pathogen panels getting denied more often?

Many Medicare Administrative Contractors and commercial payers now limit 6-11 and 12-25 target panels (87632, 87633, 87506, 87507) to patients with serious illness, immunodeficiency, or a documented severe underlying condition, treating routine outpatient triage testing at that scale as not medically necessary. Coverage policies have shifted meaningfully since these panels first became widely available.
Two-tier testing, used for Lyme disease and several other infectious diseases, requires an initial screening test followed by a confirmatory test only when the screen is reactive or equivocal. Billing the confirmatory test without a documented reactive screen, or failing to bill it at all when one was warranted, are both common and costly errors.
Typically 6-9% of net collections, reflecting the coding complexity and the pace of policy change specific to molecular infectious disease testing. TransLabs charges transparently with no setup fees, tech fees, or long-term contracts. Revenue gains from accurate panel-tier coding and reduced denials usually offset the fee within 30-60 days.
Typically 6-9% of net collections, reflecting the coding complexity specific to reflex serology and dose-unit immunotherapy billing. TransLabs charges transparently with no setup fees, tech fees, or long-term contracts. Revenue gains from reflex capture and dose accuracy usually offset the fee within 30-60 days.
Yes. Our coders handle the full infectious disease test menu, including respiratory and GI multiplex panels, STI NAAT testing, hepatitis serology and molecular panels, HIV and syphilis testing, Lyme disease two-tier testing, and TB IGRA testing.
Industry benchmark runs 10-14%, reflecting the medical necessity scrutiny specific to expanded panels. TransLabs clients typically operate below 5%. Common denial drivers include expanded panel non-coverage, target-count miscoding, and missing reflex testing documentation.
Yes, continuously. Coverage determinations for multiplex infectious disease panels change more frequently than almost any other lab category as new PLA codes are introduced and older ones are reevaluated. TransLabs updates your billing rules the moment a relevant policy changes, not after a batch of denials arrives.
Yes, we’ve integrated with laboratory information systems commonly used in serology and molecular infectious disease testing, including automated reflex triggers, target-count validation, and charge capture, typically completed within two weeks.
Most labs see results within 60-90 days: onboarding and credentialing in the first 30 days, expanded panel and reflex-related denial improvement by day 60, and by day 90, a documented clean claims rate above 95% with measurable revenue growth in a performance report.

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